Nano Bubble Absorption into the Blood stream
Nano bubbles, small gas bubbles, can be absorbed into the human gut and bloodstream, potentially enhancing drug delivery and oxygenation, but their stability and interactions with the body require further investigation.
Here’s a more detailed explanation:
What are Nano bubbles?
- Nanobubbles are tiny gas bubbles, typically smaller than 500 nanometers in diameter.
- They are being explored for various biomedical applications, including drug delivery, imaging, and oxygenation.
- Their small size allows for potential extravasation from blood vessels into surrounding tissues and ultrasound-targeted site-specific release.
Oxygen Nanobubble configuration and mechanism of 5mC hypermethylation. (a) Schematic representation of oxygen nanobubble; (b) Oxygen nanobubbles (red arrows) localize within HeLa cells in the cytoplasm as well as the nucleus. Significantly enhanced dark field microscopy images are provided. Scale bar = 10 µm.
Absorption and Circulation:
- Gut Absorption:
Nanobubbles can be administered orally, and studies have shown that they can be absorbed into the bloodstream through the gut.
- Bloodstream Interaction:
Once in the bloodstream, nanobubbles can interact with red blood cells (RBCs) and other blood components.
- Enhanced Circulation:
Some research suggests that nanobubbles can extend their circulation time in the bloodstream, potentially improving drug delivery efficiency.
Potential Applications:
- Drug Delivery:
Nanobubbles can be used as carriers for drugs, allowing for targeted delivery to specific tissues or organs.
- Ultrasound Contrast Agents:
Their ability to oscillate under ultrasound waves makes them useful as contrast agents for imaging.
- Oxygen Delivery:
Oxygen-loaded nanobubbles can improve tissue oxygenation, which is important for treating conditions like hypoxia and cancer.
- Theranostic Agents:
Nanobubbles can be designed to function as both imaging agents and drug delivery systems, making them valuable for theranostic applicatio